TYROBP genetic variants in early-onset Alzheimer's disease.

doi:10.1016/j.neurobiolaging.2016.07.028

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Article

TYROBP genetic variants in early-onset Alzheimer's disease.

Neurobiology of aging - 1 Dec 2016

Pottier Cyril, Ravenscroft Thomas A, Brown Patricia H, Finch NiCole A, Baker Matt, Parsons Meeia, Asmann Yan W, Ren Yingxue, Christopher Elizabeth, Levitch Denise, van Blitterswijk Marka, Cruchaga Carlos, Campion Dominique, Nicolas Gaël, Richard Anne-Claire, Guerreiro Rita, Bras Jose T, Zuchner Stephan, Gonzalez Michael A, Bu Guojun, Younkin Steven, Knopman David S, Josephs Keith A, Parisi Joseph E, Petersen Ronald C, Ertekin-Taner Nilüfer, Graff-Radford Neill R, Boeve Bradley F, Dickson Dennis W, Rademakers Rosa

Abstract excerpt

We aimed to identify new candidate genes potentially involved in early-onset Alzheimer's disease (EOAD). Exome sequencing was conducted on 45 EOAD patients with either a family history of Alzheimer's disease (AD, <65 years) or an extremely early age at the onset (≤55 years) followed by multiple variant filtering according to different modes of inheritance. We identified 29 candidate genes potentially involved in...

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Identifiers

PMID: 27658901
DOI: 10.1016/j.neurobiolaging.2016.07.028
PMCID: PMC5159294

Genes

TYROBP
TREM2

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