Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Jun 2023

Hancox J C, Du C Y, Butler A, Zhang Y, Dempsey C E, Harmer S C, Zhang H

Abstract excerpt

The congenital short QT syndrome (SQTS) is a rare condition characterized by abbreviated rate-corrected QT (QTc) intervals on the electrocardiogram and by increased susceptibility to both atrial and ventricular arrhythmias and sudden death. Although mutations to multiple genes have been implicated in the SQTS, evidence of causality is particularly strong for the first three (SQT1-3) variants: these result from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Arrhythmias, Cardiac

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiac electrophysiology and arrhythmias

Share to ECG Monitoring and Analysis

Share to Gain of Function Mutation

Share to Ion channel regulation and function

Share to Mutation

Share to Potassium Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 37122211
DOI: 10.1098/rstb.2022.0165
PMCID: PMC10150212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome.PMID 37122211Read ↗

A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene.Semantic proximity Read ↗

Emerging therapeutic targets in the short QT syndrome.Semantic proximity Read ↗

Congenital short QT syndrome: landmarks of the newest arrhythmogenic cardiac channelopathy.Semantic proximity Read ↗

Alleviating the Effects of Short QT Syndrome Type 3 by Allele-Specific Suppression of the KCNJ2 Mutant Allele.Semantic proximity Read ↗

In silico investigation of a KCNQ1 mutation associated with short QT syndrome.Semantic proximity Read ↗

The genetic basis of long QT and short QT syndromes: a mutation update.Semantic proximity Read ↗

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational ModellingSemantic proximity Read ↗

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria.Semantic proximity Read ↗

Mutation in the KCNQ1 gene leading to the short QT-interval syndrome.Semantic proximity Read ↗

The Kir2.1E299V mutation increases atrial fibrillation vulnerability while protecting the ventricles against arrhythmias in a mouse model of short QT syndrome type 3.Semantic proximity Read ↗

Short QT syndrome. Genotype-phenotype correlations.Semantic proximity Read ↗

The short QT syndrome as a paradigm to understand the role of potassium channels in ventricular fibrillation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.