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Article

Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome.

PLoS computational biology - 1 Dec 2011

Adeniran Ismail, McPate Mark J, Witchel Harry J, Hancox Jules C, Zhang Henggui

Abstract excerpt

The short QT syndrome (SQTS) is a genetically heterogeneous condition characterized by abbreviated QT intervals and an increased susceptibility to arrhythmia and sudden death. This simulation study identifies arrhythmogenic mechanisms in the rapid-delayed rectifier K(+) current (I(Kr))-linked SQT1 variant of the SQTS. Markov chain (MC) models were found to be superior to Hodgkin-Huxley (HH) models in reproducing...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22194679
DOI: 10.1371/journal.pcbi.1002313
PMCID: PMC3240585

Genes

KCNH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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