Article
MAVS-mediated host cell defense is inhibited by Borna disease virus.
The international journal of biochemistry & cell biology - 1 Aug 2013
Li Yujun, Song Wuqi, Wu Jing, Zhang Qingmeng, He Junming, Li Aimei, Qian Jun, Zhai Aixia, Hu Yunlong, Kao Wenping, Wei Lanlan, Zhang Fengmin, Xu Dakang
Abstract excerpt
Viruses often have strategies for preventing host cell apoptosis, which antagonizes viral replication. Borna disease virus (BDV) is a neurotropic RNA virus that establishes a non-cytolytic persistent infection. Although BDV suppresses type I Interferon (IFN) through (TANK)-binding kinase 1 (TBK-1) associated BDV P protein, it is still unclear how BDV can survive in the host cell and establish a persistent...
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