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Virus subtype-specific suppression of MAVS aggregation and activation by PB1-F2 protein of influenza A (H7N9) virus

8 Jun 2020

Abstract excerpt

Human infection with avian influenza A (H5N1) and (H7N9) viruses causes severe respiratory diseases.PB1-F2 protein is a critical virulence factor that suppresses early type I interferon response, but the mechanism of its action in relation to high pathogenicity is not well understood.Here we show that PB1-F2 protein of H7N9 virus is a particularly potent suppressor of antiviral signaling through formation of...

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PMID: 32511263
DOI: 10.1371/journal.ppat.1008611

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