Article
Detection of Driver and Resistance Mutations in Leptomeningeal Metastases of NSCLC by Next-Generation Sequencing of Cerebrospinal Fluid Circulating Tumor Cells.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2017
Jiang Ben-Yuan, Li Yang-Si, Guo Wei-Bang, Zhang Xu-Chao, Chen Zhi-Hong, Su Jian, Zhong Wen-Zhao, Yang Xue-Ning, Yang Jin-Ji, Shao Yang, Huang Biao, Liu Yan-Hui, Zhou Qing, Tu Hai-Yan, Chen Hua-Jun, Wang Zhen, Xu Chong-Rui, Wang Bin-Chao, Wu Shu-Yu, Gao Cun-Yi, Zhang Xian, Wu Yi-Long
Abstract excerpt
Purpose: Leptomeningeal metastases are more common in non-small cell lung cancer (NSCLC) with EGFR mutations. The diagnosis is difficult by traditional imaging only, and leads to poor understanding of resistance mechanisms of leptomeningeal metastases.Experimental Design: We compared the CellSearch Assay, the Thinprep cytologic test (TCT), and brain magnetic resonance imaging (MRI) in 21 NSCLC patients with...
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