Article
The frequency of candidate alleles for CYP2D6 genotyping in the Japanese population with an additional respect to the -1584C to G substitution.
Drug metabolism and pharmacokinetics - 1 Apr 2005
Ikenaga Yuka, Fukuda Tsuyoshi, Fukuda Kazuhiro, Nishida Yuko, Naohara Masakazu, Maune Hiromi, Azuma Junichi
Abstract excerpt
The -1584C/G single nucleotide polymorphism (SNP) in the promoter region of CYP2D6 was suggested to have the potential to influence CYP2D6 activity. In this report, we demonstrated the frequencies of -1584C to G substitution-related alleles, such as CYP2D6*2, CYP2D6*21, CYP2D6*35 and CYP2D6*41, in the Japanese population. The frequencies of CYP2D6*2, *41 and *21 were 0.102, 0.026 and 0.005, respectively. We also...
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