Article
CloudNeo: a cloud pipeline for identifying patient-specific tumor neoantigens.
Bioinformatics (Oxford, England) - 1 Oct 2017
Bais Preeti, Namburi Sandeep, Gatti Daniel M, Zhang Xinyu, Chuang Jeffrey H
Abstract excerpt
SUMMARY: We present CloudNeo, a cloud-based computational workflow for identifying patient-specific tumor neoantigens from next generation sequencing data. Tumor-specific mutant peptides can be detected by the immune system through their interactions with the human leukocyte antigen complex, and neoantigen presence has recently been shown to correlate with anti T-cell immunity and efficacy of checkpoint inhibitor...
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