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Article

GIPC2 interacts with Fzd7 to promote prostate cancer metastasis by activating WNT signaling

28 Mar 2022

Abstract excerpt

Prostate cancer (PCa) causes significant mortality and morbidity, with advanced metastasis. WNT signaling is a promising therapeutic target for metastatic PCa. GIPC2 is a GIPC1 paralog involved in WNT signaling pathways associated with tumor progression, but its role in PCa metastasis remains unclear. Herein, we demonstrated that high GIPC2 expression in PCa tissues was significantly associated with distant...

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PMID: 35347223
DOI: 10.1038/s41388-022-02255-4

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