Article
Production and Characterization of Self-Assembled Virus-like Particles Comprising Capsid Proteins from Genotypes 3 and 4 Hepatitis E Virus (HEV) and Rabbit HEV Expressed in Escherichia coli.
Viruses - 31 Aug 2024
Kobayashi Tominari, Takahashi Masaharu, Ohta Satoshi, Hoshino Yu, Yamada Kentaro, Jirintai Suljid, Primadharsini Putu Prathiwi, Nagashima Shigeo, Murata Kazumoto, Okamoto Hiroaki
Abstract excerpt
The zoonotic transmission of hepatitis E virus (HEV) genotypes 3 (HEV-3) and 4 (HEV-4), and rabbit HEV (HEV-3ra) has been documented. Vaccination against HEV infection depends on the capsid (open reading frame 2, ORF2) protein, which is highly immunogenic and elicits effective virus-neutralizing antibodies. Escherichia coli (E. coli) is utilized as an effective system for producing HEV-like particles (VLPs)....
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