Article
Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics.
eLife - 8 Apr 2021
Serrano-Lopez Juana, Hegde Shailaja, Kumar Sachin, Serrano Josefina, Fang Jing, Wellendorf Ashley M, Roche Paul A, Rangel Yamileth, Carrington Leolene J, Geiger Hartmut, Grimes H Leighton, Luther Sanjiv, Maillard Ivan, Sanchez-Garcia Joaquin, Starczynowski Daniel T, Cancelas Jose A
Abstract excerpt
Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the emergent activation of a previously unrecognized system of rapid migration of granulocyte-macrophage progenitors and committed macrophage-dendritic progenitors, but not...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.