Article
O-mannosylation precedes and potentially controls the N-glycosylation of a yeast cell wall glycoprotein.
EMBO reports - 1 Jun 2003
Ecker Margit, Mrsa Vladimir, Hagen Ilja, Deutzmann Rainer, Strahl Sabine, Tanner Widmar
Abstract excerpt
Secretory proteins in yeast are N- and O-glycosylated while they enter the endoplasmic reticulum. N-glycosylation is initiated by the oligosaccharyl transferase complex and O-mannosylation is initiated by distinct O-mannosyltransferase complexes of the protein mannosyl transferase Pmt1/Pmt2 and Pmt4 families. Using covalently linked cell-wall protein 5 (Ccw5) as a model, we show that the Pmt4 and Pmt1/Pmt2...
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