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Article

Inhalation exposure to cigarette smoke and inflammatory agents induces epigenetic changes in the lung

9 Jul 2020

Abstract excerpt

Smoking-related lung tumors are characterized by profound epigenetic changes including scrambled patterns of DNA methylation, deregulated histone acetylation, altered gene expression levels, distorted microRNA profiles, and a global loss of cytosine hydroxymethylation marks. Here, we employed an enhanced version of bisulfite sequencing (RRBS/oxRRBS) followed by next generation sequencing to separately map DNA...

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PMID: 32647312
DOI: 10.1038/s41598-020-67502-8

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