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Article

ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity

8 Jun 2017

Abstract excerpt

The zinc metalloprotease ZMPSTE24 is a constitutively and ubiquitously expressed host restriction factor that is responsible for limiting infection by a broad spectrum of enveloped viruses, including influenza A, vesicular stomatitis, zika, ebola, Sindbis, cowpox, and vaccinia viruses, but not murine leukemia or adenovirus. Antiviral function is independent of ZMPSTE24 enzymatic activity. Protein interaction and...

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PMID: 28594571
DOI: 10.1089/dna.2017.3791

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