Influence of two variants of CYP450 oxidoreductase on the stable dose of acenocoumarol in a Spanish population.

doi:10.2217/pgs-2017-0021

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Article

Influence of two variants of CYP450 oxidoreductase on the stable dose of acenocoumarol in a Spanish population.

Pharmacogenomics - 1 Jun 2017

Tong Hoi Y, Borobia Alberto M, Martínez Ávila José Carlos, Lubomirov Rubin, Muñoz Mario, Blanco Bañares María J, Hernández Rafael, Fernández Capitán Carmen, Ramírez Elena, Frías Jesús, Carcas Antonio J

Abstract excerpt

AIM: To evaluate the influence of two variants of P450 oxidoreductase (POR), rs2868177 and POR*28, on the stable dosage of acenocoumarol. PATIENTS & METHODS: For this observational, cross-sectional study, patients were undergone stable anticoagulant treatment with acenocoumarol. Univariate and multiple regression analyses were performed to assess the influence of POR polymorphisms. RESULTS: About 340 patients...

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PMID: 28592191
DOI: 10.2217/pgs-2017-0021

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