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Article

Tailoring protein nanomechanics with chemical reactivity.

Nature communications - 6 Jun 2017

Beedle Amy E M, Mora Marc, Lynham Steven, Stirnemann Guillaume, Garcia-Manyes Sergi

Abstract excerpt

The nanomechanical properties of elastomeric proteins determine the elasticity of a variety of tissues. A widespread natural tactic to regulate protein extensibility lies in the presence of covalent disulfide bonds, which significantly enhance protein stiffness. The prevalent in vivo strategy to form disulfide bonds requires the presence of dedicated enzymes. Here we propose an alternative chemical route to...

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Identifiers

PMID: 28585528
DOI: 10.1038/ncomms15658
PMCID: PMC5467162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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