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Article

A Potent EGFR Inhibitor, N-Phenyl Pyrazoline Derivative Suppresses Aggressiveness and Cancer Stem Cell-Like Phenotype of Cervical Cancer Cells.

Drug design, development and therapy - 1 Jan 2022

Mustofa, Satriyo Pamungkas Bagus, Suma Artania Adnin Tri, Waskitha Stephanus Satria Wira, Wahyuningsih Tutik Dwi, Sholikhah Eti Nurwening

Abstract excerpt

Objective: Metastasis causes approximately 90% of cancer-related deaths, including in cervical cancer patients. Uncontrolled cell proliferation, migration, and cancer stemness act as critical events in primary tumor growth and cancer metastasis progression in cervical cancer. Here, we investigated the anti-proliferative, anti-migration, and cancer stemness inhibition activity of N-phenyl pyrazoline derivatives...

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Identifiers

PMID: 35899233
DOI: 10.2147/DDDT.S350913
PMCID: PMC9309293

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