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Differentiation therapy of hepatocellular carcinoma by inhibiting the activity of AKT/GSK-3β/β-catenin axis and TGF-β induced EMT with sophocarpine.

Cancer letters - 28 Jun 2016

Zhang Ping-Ping, Wang Pei-Qin, Qiao Chun-Ping, Zhang Qing, Zhang Jun-Ping, Chen Fei, Zhang Xin, Xie Wei-Fen, Yuan Zong-Li, Li Zhao-Shen, Chen Yue-Xiang

Abstract excerpt

Hepatocellular carcinoma progression is thought to be driven by cancer stem cells (CSCs). No clinical trial has, as yet, shown convincing long-term disease free survival results for the majority of patients in HCC. So it is important to discover new anti-cancer agents. In our study, we chose sophocarpine, which is derived from the foxtail-like sophora herb, for its efficacy to inhibit HCC including CSCs and...

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PMID: 26945965
DOI: 10.1016/j.canlet.2016.01.011

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