Article
Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype.
Cancer research - 1 Apr 2016
Li Ling, Li Chao, Wang Shaoxin, Wang Zhaohui, Jiang Jian, Wang Wei, Li Xiaoxia, Chen Jin, Liu Kun, Li Chunhua, Zhu Guiquan
Abstract excerpt
Hypoxia is a common feature of solid tumors and is associated with aggressiveness and poor patient outcomes. Exosomes, initially considered to be cellular "garbage dumpsters," are now implicated in mediating interactions with the cellular environment. However, the mechanisms underlying the association between exosomes and hypoxia during cancer progression remain poorly understood. In this study, we found that...
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