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Article

Mendelian randomization in cardiometabolic disease: challenges in evaluating causality.

Nature reviews. Cardiology - 1 Oct 2017

Holmes Michael V, Ala-Korpela Mika, Smith George Davey

Abstract excerpt

Mendelian randomization (MR) is a burgeoning field that involves the use of genetic variants to assess causal relationships between exposures and outcomes. MR studies can be straightforward; for example, genetic variants within or near the encoding locus that is associated with protein concentrations can help to assess their causal role in disease. However, a more complex relationship between the genetic variants...

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Biomarkers
Cholesterol, HDL
Cholesterol, LDL
Coronary Disease
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Multifactorial Inheritance

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Identifiers

PMID: 28569269
DOI: 10.1038/nrcardio.2017.78
PMCID: PMC5600813

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