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Article

Metabolomic profiling in a Hedgehog Interacting Protein (Hhip) murine model of chronic obstructive pulmonary disease.

Scientific reports - 31 May 2017

Wan Emily S, Li Yan, Lao Taotao, Qiu Weiliang, Jiang Zhiqiang, Mancini John D, Owen Caroline A, Clish Clary, DeMeo Dawn L, Silverman Edwin K, Zhou Xiaobo

Abstract excerpt

Genetic variants annotated to the hedgehog interacting protein (HHIP) are robustly associated with chronic obstructive pulmonary disease (COPD). Hhip haploinsufficiency in mice leads to increased susceptibility towards the development of emphysema following exposure to chronic cigarette smoke (CS). To explore the molecular pathways which contribute to increased susceptibility, we performed metabolomic profiling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28566717
DOI: 10.1038/s41598-017-02701-4
PMCID: PMC5451406

Genes

HHIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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