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Article

Structural Basis for Regulation of ESCRT-III Complexes by Lgd.

Cell reports - 30 May 2017

McMillan Brian J, Tibbe Christine, Drabek Andrew A, Seegar Tom C M, Blacklow Stephen C, Klein Thomas

Abstract excerpt

The ESCRT-III complex induces outward membrane budding and fission through homotypic polymerization of its core component Shrub/CHMP4B. Shrub activity is regulated by its direct interaction with a protein called Lgd in flies, or CC2D1A or B in humans. Here, we report the structural basis for this interaction and propose a mechanism for regulation of polymer assembly. The isolated third DM14 repeat of Lgd binds...

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Identifiers

PMID: 28564595
DOI: 10.1016/j.celrep.2017.05.026
PMCID: PMC5528166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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