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Article

Diagnostic utility of IDH1/2 mutations to distinguish dedifferentiated chondrosarcoma from undifferentiated pleomorphic sarcoma of bone.

Human pathology - 1 Jul 2017

Chen Shaoxiong, Fritchie Karen, Wei Shi, Ali Naser, Curless Kendra, Shen Tiansheng, Brini Anna T, Latif Farida, Sumathi Vaiyapuri, Siegal Gene P, Cheng Liang

Abstract excerpt

Histologically, it is nearly impossible to distinguish the dedifferentiated component of dedifferentiated chondrosarcoma from undifferentiated pleomorphic sarcoma (UPS) of bone when the low-grade cartilaginous component is absent. Previous studies have revealed that isocitrate dehydrogenase 1 (IDH1) and IDH2 mutations are present in a significant number of cartilaginous tumors including most conventional...

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Source

Identifiers

PMID: 28552826
DOI: 10.1016/j.humpath.2017.05.015

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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