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Article

Apomorphine Therapy for Neuronal Insulin Resistance in a Mouse Model of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Nakamura Norimichi, Ohyagi Yasumasa, Imamura Tomohiro, Yanagihara Yuki T, Iinuma Kyoko M, Soejima Naoko, Murai Hiroyuki, Yamasaki Ryo, Kira Jun-Ichi

Abstract excerpt

Apomorphine (APO) promotes intraneuronal amyloid-β (Aβ) degradation and improves memory function in an Alzheimer's disease (AD) model, 3xTg-AD mice. Since insulin resistance is increased in AD neurons, we investigated the effects of APO on brain insulin resistance in 3xTg-AD mice at early and late stages. After 1-month subcutaneous injection of Apokyn® to 3xTg-AD mice at 6 or 12 months of age, memory function was...

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PMID: 28550243
DOI: 10.3233/JAD-160344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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