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Article

Tudor-SN–mediated endonucleolytic decay of human cell microRNAs promotes G 1 /S phase transition

25 May 2017

Abstract excerpt

Breaking down miRNAs Although much work has examined microRNA (miRNA) biogenesis, relatively little is known about miRNA decay. Elbarbary et al. now identify Tudor-SN, an endonuclease that interacts with the RNA-induced silencing complex. Tudor-SN targets miRNAs at CA and UA dinucleotides located more than five nucleotides from miRNA ends. Tudor-SN-mediated miRNA decay removes miRNAs that silence genes encoding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28546213
DOI: 10.1126/science.aai9372

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