Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Viral microRNA Down-Regulates Multiple Cell Cycle Genes through mRNA 5′UTRs

24 Jun 2010

Abstract excerpt

Global gene expression data combined with bioinformatic analysis provides strong evidence that mammalian miRNAs mediate repression of gene expression primarily through binding sites within the 3' untranslated region (UTR). Using RNA induced silencing complex immunoprecipitation (RISC-IP) techniques we have identified multiple cellular targets for a human cytomegalovirus (HCMV) miRNA, miR-US25-1. Strikingly, this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to MicroRNA in disease regulation
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20585629
DOI: 10.1371/journal.ppat.1000967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Viral microRNA Down-Regulates Multiple Cell Cycle Genes through mRNA 5′UTRsPMID 20585629Read ↗

Human cytomegalovirus microRNA miR-US25-1-5p inhibits viral replication by targeting multiple cellular genes during infectionSemantic proximity Read ↗

Human Cytomegalovirus US7 Is Regulated Synergistically by Two Virally Encoded MicroRNAs and by Two Distinct MechanismsSemantic proximity Read ↗

Human Cytomegalovirus miR-UL148D Facilitates Latent Viral Infection by Targeting Host Cell Immediate Early Response Gene 5Semantic proximity Read ↗

Systematic Analysis of Viral and Cellular MicroRNA Targets in Cells Latently Infected with Human γ-Herpesviruses by RISC Immunoprecipitation AssaySemantic proximity Read ↗

Systematic MicroRNA Analysis Identifies ATP6V0C as an Essential Host Factor for Human Cytomegalovirus ReplicationSemantic proximity Read ↗

Regulation of the Cell Cycle by ncRNAs Affects the Efficiency of CDK4/6 InhibitionSemantic proximity Read ↗

Regulation of Latency and Reactivation by Human Cytomegalovirus miRNAsSemantic proximity Read ↗

Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expressionSemantic proximity Read ↗

Viruses and microRNAs: RISCy interactions with serious consequences.Semantic proximity Read ↗

Exploring Mechanisms of MicroRNA Downregulation in Cancer.Semantic proximity Read ↗

Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1Semantic proximity Read ↗

High-Resolution Profiling and Analysis of Viral and Host Small RNAs during Human Cytomegalovirus InfectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.