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Article

A score test for genetic class-level association with nonlinear biomarker trajectories.

Statistics in medicine - 30 Aug 2017

Qian Jing, Nunez Sara, Kim Soohyun, Reilly Muredach P, Foulkes Andrea S

Abstract excerpt

Emerging data suggest that the genetic regulation of the biological response to inflammatory stress may be fundamentally different to the genetic underpinning of the homeostatic control (resting state) of the same biological measures. In this paper, we interrogate this hypothesis using a single-SNP score test and a novel class-level testing strategy to characterize protein-coding gene and regulatory element-level...

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Identifiers

PMID: 28543585
DOI: 10.1002/sim.7314
PMCID: PMC6002775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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