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Article

An appraisal of the enzyme stability-activity trade-off.

Evolution; international journal of organic evolution - 1 Jul 2017

Miller Scott R

Abstract excerpt

A longstanding idea in evolutionary physiology is that an enzyme cannot jointly optimize performance at both high and low temperatures due to a trade-off between stability and activity. Although a stability-activity trade-off has been observed for well-characterized examples, such a trade-off is not imposed by any physical chemical constraint. To better understand the pervasiveness of this trade-off, I...

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PMID: 28542908
DOI: 10.1111/evo.13275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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