Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inter-patient and Intra-tumor Heterogeneity in the Sensitivity to Tumor-targeted Immunity in Colorectal Cancer.

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology - 1 Jan 2017

Miyauchi Tsubasa, Yaguchi Tomonori, Kawakami Yutaka

Abstract excerpt

Efficacy of immune checkpoint inhibitors such as PD-1 antibody for colorectal cancer remains to be proved except in microsatellite-instability-high (MSI-H) cases. While the objective response rate of MSI-H cases was 40%, that of microsatellite-stable (MSS) cases was 0%, showing that response rate to immune checkpoint inhibitors varies even among the microsatellite status. Some possible mechanisms that confer each...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Autophagy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Polymerase II

Share to Immunotherapy

Share to Microsatellite Instability

Share to Poly-ADP-Ribose Binding Proteins

Share to Programmed Cell Death 1 Receptor

Share to Receptors, Nerve Growth Factor

Source

Identifiers

PMID: 28539555
DOI: 10.2177/jsci.40.54

Genes

POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inter-patient and Intra-tumor Heterogeneity in the Sensitivity to Tumor-targeted Immunity in Colorectal Cancer.PMID 28539555Read ↗

Relationship between microsatellite status and immune microenvironment of colorectal cancer and its application to diagnosis and treatmentSemantic proximity Read ↗

Crosstalk Between the MSI Status and Tumor Microenvironment in Colorectal Cancer.Semantic proximity Read ↗

Intratumor Heterogeneity and Antitumor Immunity Shape One Another Bidirectionally.Semantic proximity Read ↗

Genomic and transcriptomic characterization of heterogeneous immune subgroups of microsatellite instability-high colorectal cancers.Semantic proximity Read ↗

Prognostic implication of CD274 (PD-L1) protein expression in tumor-infiltrating immune cells for microsatellite unstable and stable colorectal cancer.Semantic proximity Read ↗

Intratumor heterogeneity: the hidden barrier to immunotherapy against MSI tumors from the perspective of IFN-γ signaling and tumor-infiltrating lymphocytesSemantic proximity Read ↗

Immunotherapy of microsatellite stable colorectal cancer: resistance mechanisms and treatment strategies.Semantic proximity Read ↗

Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers.Semantic proximity Read ↗

Tumor Infiltrating Lymphocytes and Macrophages Improve Survival in Microsatellite Unstable Colorectal CancerSemantic proximity Read ↗

Analysis of the molecular nature associated with microsatellite status in colon cancer identifies clinical implications for immunotherapySemantic proximity Read ↗

Tumor mutational burden predicts neoantigen profiles and immunotherapy response in microsatellite stable tumors across different cancer types.Semantic proximity Read ↗

Intratumor heterogeneity: A new perspective on colorectal cancer research.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.