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Article

Immunotherapy of microsatellite stable colorectal cancer: resistance mechanisms and treatment strategies.

Postgraduate medical journal - 18 May 2024

Han Yan-Jie, Shao Chi-Yun, Yao Ying, Zhang Zhe, Fang Ming-Zhi, Gong Tao, Zhang Ya-Jie, Li Min

Abstract excerpt

In recent years, immunotherapy strategies based on immune checkpoint inhibitors have yielded good efficacy in colorectal cancer (CRC)especially in colorectal cancer with microsatellite instability-high. However, microsatellite-stable (MSS) CRCs account for about 85% of CRCs and are resistant to immunotherapy. Previous studies have shown that compared with MSS CRC, high microsatellite instability CRC possesses a...

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PMID: 38211949
DOI: 10.1093/postmj/qgad136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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