Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Moderately Elevated Homocysteine Does Not Contribute to Thoracic Aortic Aneurysm in Mice.

The Journal of nutrition - 1 Jul 2017

Roohi Jasmin, Kang Benjamin, Bernard David, Bedja Djahida, Dietz Harry C, Brody Lawrence C

Abstract excerpt

Background: Moderate hyperhomocysteinemia is an attractive target for intervention because it is present in 5-7% of the population and can be reversed by diet. This approach presupposes that hyperhomocysteinemia is directly involved in the disease process. Epidemiologic studies have indicated that moderately elevated homocysteine may contribute to thoracic aortic aneurysm (TAA) dilatation and dissection in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic Aneurysm, Thoracic
Share to Fibrillin-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homocysteine

Share to Hyperhomocysteinemia

Share to Marfan Syndrome

Share to Mice, Inbred C57BL

Share to Vitamin B 12

Share to Vitamin B 12 Deficiency

Source

Open in PubMed Open full text

Identifiers

PMID: 28539414
DOI: 10.3945/jn.117.251173
PMCID: PMC5483969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Moderately Elevated Homocysteine Does Not Contribute to Thoracic Aortic Aneurysm in Mice.PMID 28539414Read ↗

Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.Semantic proximity Read ↗

Role of hyperhomocysteinemia in aortic disease.Semantic proximity Read ↗

Homocysteine metabolism.Semantic proximity Read ↗

The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation.Semantic proximity Read ↗

MTHFR variant links homocysteine metabolism and endothelial cell dysfunction by targeting mitophagy in human thoracic aortic dissection patient induced pluripotent stem cell (iPSC) modelsSemantic proximity Read ↗

Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+ Marfan Mouse Model.Semantic proximity Read ↗

Phenotypic variability of cardiovascular manifestations in Marfan Syndrome. Possible role of hyperhomocysteinemia and C677T MTHFR gene polymorphism.Semantic proximity Read ↗

Murine models of hyperhomocysteinemia and their vascular phenotypes.Semantic proximity Read ↗

Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency.Semantic proximity Read ↗

Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency.Semantic proximity Read ↗

Associations of global DNA methylation and homocysteine levels with abdominal aortic aneurysm: A cohort study from a population-based screening program in SwedenSemantic proximity Read ↗

Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.