Article
Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression.
Genes & development - 15 Aug 2017
Yue Xuetian, Zhang Cen, Zhao Yuhan, Liu Juan, Lin Alan W, Tan Victor M, Drake Justin M, Liu Lianxin, Boateng Michael N, Li Jun, Feng Zhaohui, Hu Wenwei
Abstract excerpt
Tumor suppressor p53 is frequently mutated in human cancer. Mutant p53 often promotes tumor progression through gain-of-function (GOF) mechanisms. However, the mechanisms underlying mutant p53 GOF are not well understood. In this study, we found that mutant p53 activates small GTPase Rac1 as a critical mechanism for mutant p53 GOF to promote tumor progression. Mechanistically, mutant p53 interacts with Rac1 and...
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