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TAM Receptor Tyrosine Kinases in Cancer Drug Resistance

19 May 2017

Abstract excerpt

Abstract Receptor tyrosine kinases (RTK) are major regulators of key biological processes, including cell growth, survival, and differentiation, and were established early on as proto-oncogenes, with aberrant expression linked to tumor progression in many cancers. Therefore, RTKs have emerged as major targets for selective therapy with small-molecule inhibitors. However, despite improvements in survival rates, it...

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PMID: 28526769
DOI: 10.1158/0008-5472.can-16-2675

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