Article
Validated Bayesian Differentiation of Causative and Passenger Mutations.
G3 (Bethesda, Md.) - 5 Jul 2017
Cross Frederick R, Breker Michal, Lieberman Kristi
Abstract excerpt
In many contexts, the problem arises of determining which of many candidate mutations is the most likely to be causative for some phenotype. It is desirable to have a way to evaluate this probability that relies as little as possible on previous knowledge, to avoid bias against discovering new genes or functions. We have isolated mutants with blocked cell cycle progression in Chlamydomonas and determined mutant...
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