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Article

XLF-mediated NHEJ activity in hepatocellular carcinoma therapy resistance

19 May 2017

Abstract excerpt

BACKGROUND: DNA repair pathways are used by cancer cells to overcome many standard anticancer treatments, causing therapy resistance. Here, we investigated the role of XRCC4-like factor (XLF), a core member of the non-homologous end joining (NHEJ) repair pathway, in chemoresistance in hepatocellular carcinoma (HCC). METHODS: qRT-PCR analysis and western blotting were performed to detect expression levels of genes...

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PMID: 28526069
DOI: 10.1186/s12885-017-3345-y

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