Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL

29 Jan 2024

Abstract excerpt

BACKGROUND: Hepatocellular Carcinoma (HCC) is a matter of great global public health importance; however, its current therapeutic effectiveness is deemed inadequate, and the range of therapeutic targets is limited. The aim of this study was to identify early growth response 1 (EGR1) as a transcription factor target in HCC and to explore its role and assess the potential of gene therapy utilizing EGR1 for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38287371
DOI: 10.1186/s13046-024-02957-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKLPMID 38287371Read ↗

Role of early growth response 1 in liver metabolism and liver cancerSemantic proximity Read ↗

Involvement of microRNA-718, a new regulator of EGR3, in regulation of malignant phenotype of HCC cells.Semantic proximity Read ↗

Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular CarcinomaSemantic proximity Read ↗

Early growth response factor 1 promotes HCC progression by activating the MAPK/ERK pathway through transcriptional upregulation of PAR1Semantic proximity Read ↗

CGREF1 facilitates the cell proliferation, migration and invasion of hepatocellular carcinoma cells via regulation of EIF3H/ Wnt/β-Catenin signaling axisSemantic proximity Read ↗

Aldo-keto reductase family member C3 (AKR1C3) promotes hepatocellular carcinoma cell growth by producing prostaglandin F2αSemantic proximity Read ↗

Dysregulated paired related homeobox 1 impacts on hepatocellular carcinoma phenotypes.Semantic proximity Read ↗

Enolase-1 serves as a biomarker of diagnosis and prognosis in hepatocellular carcinoma patientsSemantic proximity Read ↗

Inhibition of ERN1 Signaling is Important for the Suppression of Tumor GrowthSemantic proximity Read ↗

Phosphofructokinase-1 in Cancer: A Promising Target for Diagnosis and TherapySemantic proximity Read ↗

Talin1 promotes HCC progression by regulating NRG1/PI3K/AKT axisSemantic proximity Read ↗

Mechanism of GLG1 driving malignant progression of hepatocellular carcinoma and development of targeted compound YHB-5Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.