Article
The association among cytochrome P450 3A, progesterone receptor polymorphisms, plasma 17-alpha hydroxyprogesterone caproate concentrations, and spontaneous preterm birth.
American journal of obstetrics and gynecology - 1 Sept 2017
Bustos Martha L, Caritis Steve N, Jablonski Kathleen A, Reddy Uma M, Sorokin Yoram, Manuck Tracy, Varner Michael W, Wapner Ronald J, Iams Jay D, Carpenter Marshall W, Peaceman Alan M, Mercer Brian M, Sciscione Anthony, Rouse Dwight J, Ramin Susan M
Abstract excerpt
BACKGROUND: Infants born <37 weeks' gestation are of public health concern since complications associated with preterm birth are the leading cause of mortality in children <5 years of age and a major cause of morbidity and lifelong disability. The administration of 17-alpha hydroxyprogesterone caproate reduces preterm birth by 33% in women with history of spontaneous preterm birth. We demonstrated previously that...
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