Article
Single nucleotide polymorphisms in the human progesterone receptor gene and spontaneous preterm birth.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Feb 2008
Guoyang Luo, Morgan Thomas, Bahtiyar Mert O, Snegovskikh Victoria V, Schatz Frederick, Kuczynski Edward, Funai Edmund F, Dulay Antonette T, Huang Se-Te Joseph, Buhimschi Catalin S, Buhimschi Irina A, Fortunato Stephen J, Menon Ramkumar, Lockwood Charles J, Norwitz Errol R
Abstract excerpt
Progesterone supplementation can prevent preterm birth in some high-risk women. Progesterone binds to progesterone receptor (PR) and modulates the expression of target genes. This study investigates the association between single nucleotide polymorphisms (SNPs) in the PR gene and spontaneous pret...
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