Article
Absence of mitochondrial progesterone receptor polymorphisms in women with spontaneous preterm birth.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Oct 2010
Manuck Tracy A, Price Thomas M, Thom Elizabeth, Meis Paul J, Dombrowski Mitchell P, Sibai Baha, Spong Catherine Y, Rouse Dwight J, Iams Jay D, Simhan Hyagriv N, O'Sullivan Mary J, Miodovnik Menachem, Leveno Kenneth J, Conway Deborah, Wapner Ronald J, Carpenter Marshall, Mercer Brian, Ramin Susan M, Thorp John M, Peaceman Alan M
Abstract excerpt
OBJECTIVE: The truncated mitochondrial progesterone receptor (PR-M) is homologous to nuclear PRs with the exception of an amino terminus hydrophobic membrane localization sequence, which localizes PR-M to mitochondria. Given the matrilineal inheritance of both spontaneous preterm birth (SPTB) and the mitochondrial genome, we hypothesized that (a) PR-M is polymorphic and (b) PR-M localization sequence...
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