Crimean-Congo Hemorrhagic Fever Virus Nucleocapsid Protein Augments mRNA Translation

Abstract excerpt

ABSTRACT Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne Nairovirus of the Bunyaviridae family, causing severe illness with high mortality rates in humans. Here, we demonstrate that CCHFV nucleocapsid protein (CCHFV-NP) augments mRNA translation. CCHFV-NP binds to the viral mRNA 5′ untranslated region (UTR) with high affinity. It facilitates the translation of reporter mRNA both in vivo and in vitro...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Plant Virus Research Studies
• Share to Vector-Borne Animal Diseases
• Share to Viral Infections and Vectors