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Article

Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein.

PLoS neglected tropical diseases - 1 Jun 2020

Tchesnokov Egor P, Bailey-Elkin Ben A, Mark Brian L, Götte Matthias

Abstract excerpt

BACKGROUND: The Crimean-Congo hemorrhagic fever virus (CCHFV) is a segmented negative-sense RNA virus that can cause severe human disease. The World Health Organization (WHO) has listed CCHFVas a priority pathogen with an urgent need for enhanced research activities to develop effective countermeasures. Here we adopted a biochemical approach that targets the viral RNA-dependent RNA polymerase (RdRp). The CCHFV...

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Identifiers

PMID: 32497085
DOI: 10.1371/journal.pntd.0008283
PMCID: PMC7271988

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