Article
Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations.
Cancer discovery - 1 Sept 2017
Huang Franklin W, Mosquera Juan Miguel, Garofalo Andrea, Oh Coyin, Baco Maria, Amin-Mansour Ali, Rabasha Bokang, Bahl Samira, Mullane Stephanie A, Robinson Brian D, Aldubayan Saud, Khani Francesca, Karir Beerinder, Kim Eejung, Chimene-Weiss Jeremy, Hofree Matan, Romanel Alessandro, Osborne Joseph R, Kim Jong Wook, Azabdaftari Gissou, Woloszynska-Read Anna, Sfanos Karen, De Marzo Angelo M, Demichelis Francesca, Gabriel Stacey, Van Allen Eliezer M, Mesirov Jill, Tamayo Pablo, Rubin Mark A, Powell Isaac J, Garraway Levi A
Abstract excerpt
African-American men have the highest incidence of and mortality from prostate cancer. Whether a biological basis exists for this disparity remains unclear. Exome sequencing (n = 102) and targeted validation (n = 90) of localized primary hormone-naïve prostate cancer in African-American men identified several gene mutations not previously observed in this context, including recurrent loss-of-function mutations in...
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