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Article

Epigenome-wide association study in hepatocellular carcinoma: Identification of stochastic epigenetic mutations through an innovative statistical approach.

Oncotarget - 27 Jun 2017

Gentilini Davide, Scala Stefania, Gaudenzi Germano, Garagnani Paolo, Capri Miriam, Cescon Matteo, Grazi Gian Luca, Bacalini Maria Giulia, Pisoni Serena, Dicitore Alessandra, Circelli Luisa, Santagata Sara, Izzo Francesco, Di Blasio Anna Maria, Persani Luca, Franceschi Claudio, Vitale Giovanni

Abstract excerpt

Hepatocellular carcinoma (HCC) results from accumulation of both genetic and epigenetic alterations. We investigated the genome-wide DNA methylation profile in 69 pairs of HCC and adjacent non-cancerous liver tissues using the Infinium HumanMethylation 450K BeadChip array. An innovative analytical approach has been adopted to identify Stochastic Epigenetic Mutations (SEMs) in HCC.HCC and peritumoral tissues...

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Share to Carcinogenesis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

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Source

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Identifiers

PMID: 28514750
DOI: 10.18632/oncotarget.17462
PMCID: PMC5522036

Genes

ADARB2
AJAP1
PTPRN2
SDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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