Article
A variant in SIRT2 gene 3'-UTR is associated with susceptibility to colorectal cancer.
Oncotarget - 20 Jun 2017
Yang Yong, Ding Jie, Gao Zhi-Gang, Wang Zhen-Jun
Abstract excerpt
SIRT2 is a member of sirtuin family and is associated with cell growth in various cancers. In this study, we searched for variants in functional region of SIRT2 gene and identify rs2015 and rs2241703 in the 3'UTR with minor allele frequency >0.05 in Chinese Han Beijing population from 1000 Genomes Project. We then genotyped these two variants in 842 colorectal cancer (CRC) patients and 1,718 healthy controls...
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