Article
Normal development of spinal axons in early embryo stages and posterior locomotor function is independent of GAL-1.
The Journal of comparative neurology - 1 Sept 2017
Pasquini Juana M, Barrantes Francisco J, Quintá Héctor R
Abstract excerpt
It was recently described that Galectin-1 (Gal-1) promotes axonal growth after spinal cord injury. This effect depends on protein dimerization, since monomeric Gal-1 fails to stimulate axonal re-growth. Gal-1 is expressed in vivo at concentrations that favor the monomeric species. The aim of the present study is to investigate whether endogenous Gal-1 is required for spinal axon development and normal locomotor...
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