Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic targeting of adult Renshaw cells using a Calbindin 1 destabilized Cre allele for intersection with Parvalbumin or Engrailed1.

Scientific reports - 6 Oct 2021

Lane Alicia R, Cogdell Indeara C, Jessell Thomas M, Bikoff Jay B, Alvarez Francisco J

Abstract excerpt

Renshaw cells (RCs) are one of the most studied spinal interneurons; however, their roles in motor control remain enigmatic in part due to the lack of experimental models to interfere with RC function, specifically in adults. To overcome this limitation, we leveraged the distinct temporal regulation of Calbindin (Calb1) expression in RCs to create genetic models for timed RC manipulation. We used a Calb1 allele...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Fluorescent Antibody Technique

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Homeodomain Proteins

Share to Immunohistochemistry

Share to Integrases

Share to Mice, Transgenic

Share to Parvalbumins

Source

Open in PubMed Open full text

Identifiers

PMID: 34615947
DOI: 10.1038/s41598-021-99333-6
PMCID: PMC8494874

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic targeting of adult Renshaw cells using a Calbindin 1 destabilized Cre allele for intersection with Parvalbumin or Engrailed1.PMID 34615947Read ↗

Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneitySemantic proximity Read ↗

Tools for Cre-Mediated Conditional Deletion of Floxed Alleles from Developing Cerebellar Purkinje Cells.Semantic proximity Read ↗

Roof plate and dorsal spinal cord dl1 interneuron development in the dreher mutant mouse.Semantic proximity Read ↗

Spinal cord maturation and locomotion in mice with an isolated cortex.Semantic proximity Read ↗

Genetic Dissection of the Function of Hindbrain Axonal CommissuresSemantic proximity Read ↗

Mosaic analysis of gene function in postnatal mouse brain development by using virus-based Cre recombination.Semantic proximity Read ↗

Normal development of spinal axons in early embryo stages and posterior locomotor function is independent of GAL-1.Semantic proximity Read ↗

Deciphering the Role of Aggrecan in Parvalbumin Interneurons: Unexpected Outcomes from a Conditional ACAN Knockout That Eliminates WFA+ Perineuronal NetsSemantic proximity Read ↗

Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density.Semantic proximity Read ↗

Comparative analysis of conditional reporter alleles in the developing embryo and embryonic nervous system.Semantic proximity Read ↗

The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain.Semantic proximity Read ↗

Deletion of a conserved genomic region associated with adolescent idiopathic scoliosis leads to vertebral rotation in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.