Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TRIM32 is an E3 ubiquitin ligase for dysbindin.

Human molecular genetics - 1 Jul 2009

Locke Matthew, Tinsley Caroline L, Benson Matthew A, Blake Derek J

Abstract excerpt

Mutations in the gene encoding tripartite motif protein 32 (TRIM32) cause two seemingly diverse diseases: limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11(BBS11). Although TRIM32 is involved in protein ubiquitination, its substrates and the molecular consequences of disease-causing mutations are poorly understood. In this paper, we show that TRIM32...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dysbindin
Share to Dystrophin-Associated Proteins
Share to Muscle, Skeletal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscular Dystrophies, Limb-Girdle

Share to Protein Transport

Share to Tripartite Motif Proteins

Share to Ubiquitin-Protein Ligases

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 19349376
DOI: 10.1093/hmg/ddp167
PMCID: PMC2694686

Genes

TRIM32

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRIM32 is an E3 ubiquitin ligase for dysbindin.PMID 19349376Read ↗

Tripartite Motif-Containing Protein 32 (TRIM32): What Does It Do for Skeletal Muscle?Semantic proximity Read ↗

Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin.Semantic proximity Read ↗

The common missense mutation D489N in TRIM32 causing limb girdle muscular dystrophy 2H leads to loss of the mutated protein in knock-in mice resulting in a Trim32-null phenotype.Semantic proximity Read ↗

TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levelsSemantic proximity Read ↗

TRIM32 and Malin in Neurological and Neuromuscular Rare DiseasesSemantic proximity Read ↗

TRIM32 controls timely cell cycle exit in muscular differentiation through c-Myc down-regulationSemantic proximity Read ↗

Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H.Semantic proximity Read ↗

Altered myogenesis and premature senescence underlie human TRIM32-related myopathySemantic proximity Read ↗

Costameric integrin and sarcoglycan protein levels are altered in a Drosophila model for Limb-girdle muscular dystrophy type 2H.Semantic proximity Read ↗

TRIM32 biallelic defects cause limb-girdle muscular dystrophy R8: identification of two novel mutations and investigation of genotype-phenotype correlation.Semantic proximity Read ↗

Satellite cell senescence underlies myopathy in a mouse model of limb-girdle muscular dystrophy 2HSemantic proximity Read ↗

The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.