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Article

Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools.

Nature genetics - 1 Aug 2003

Kimura Takashi, Takeda Satoshi, Sagiya Yoji, Gotoh Mitsukazu, Nakamura Yusuke, Arakawa Hirofumi

Abstract excerpt

p53R2, which is regulated by tumor suppressor p53, is a small subunit of ribonucleotide reductase. To determine whether it is involved in DNA repair by supplying deoxyribonucleotides (dNTPs) for resting cells in vivo, we generated a strain of mice lacking Rrm2b (encoding p53R2). These mice developed normally until they were weaned but from then on had growth retardation and early mortality. Pathological...

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Source

Identifiers

PMID: 12858174
DOI: 10.1038/ng1212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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