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Article

The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53.

Cancer research - 15 Oct 2003

Zhou Bingsen, Liu Xiyong, Mo Xueli, Xue Lijun, Darwish Dana, Qiu Weihua, Shih Jennifer, Hwu Edward B, Luh Frank, Yen Yun

Abstract excerpt

Ribonucleotide reductase (RR) is responsible for the de novo conversion of the ribonucleoside diphosphates to deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair. RR consists of two subunits, hRRM1 and hRRM2. p53R2 is a new RR family member. Because the majority of human tumors possess mutant p53, it is important to know the molecular mechanism by which mutant p53 regulates RR and...

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Identifiers

PMID: 14583450

Genes

RRM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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