Article
Early childhood lung function is a stronger predictor of adolescent lung function in cystic fibrosis than early Pseudomonas aeruginosa infection.
PloS one - 1 Jan 2017
Pittman Jessica E, Noah Hannah, Calloway Hollin E, Davis Stephanie D, Leigh Margaret W, Drumm Mitchell, Sagel Scott D, Accurso Frank J, Knowles Michael R, Sontag Marci K
Abstract excerpt
OBJECTIVE: Pseudomonas aeruginosa has been suggested as a major determinant of poor pulmonary outcomes in cystic fibrosis (CF), although other factors play a role. Our objective was to investigate the association of early childhood Pseudomonas infection on differences in lung function in adolescence with CF. METHODS: Two populations of subjects with CF were studied: from the Gene Modifier Study (GMS), 346 F508del...
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